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SURMOUNT-5 was a 72-week, multi-centre, randomised, open-label, Phase 3b trial evaluating the efficacy and safety of tirzepatide compared with semaglutide in adults with obesity, or overweight with at least one of the following comorbidities: hypertension, dyslipidaemia, obstructive sleep apnoea (OSA) or cardiovascular disease, who did not have diabetes

The most common defect is a deletion on the paternal 15q11-q13 chromosome, which is seen in about 60% of individuals

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